The IR-4 Project screens new active ingredients for potential deleterious impacts to aid growers in selection of appropriate disease management tools for their crops. From 2014 to 2017, IR-4 completed 68 trials on 29 ornamental plant species examining phytotoxicity related to foliar applications of Orkestra (fluxapyroxad + pyraclostrobin). During 2016 and 2017, an additional 8 trials were conducted using drench application on 7 crops. In these trials, 13 species or genera exhibited minimal or no injury after foliar applications in a minimum of 3 trials for each crop. Nine of these are already on the current label for this active ingredient; the other four (Aquilegia sp, Hemerocallis sp., Picea sp. and Pinus sp.) can be added to a list of tolerant plants in the current label. Only two plant species (Cornus florida and Impatiens hawkeri) exhibited significant injury in one study. All trials for fifteen other species or genera exhibited no or minimal injury in the limited number of trials (one or two) for each crop. Six of these are already in the current label; BASF can consider adding the other nine to the label. Drench application caused no phytotoxicity on all crops tested.