From 2011 through 2020, IR-4 has completed 159 trials evaluating two granular and one liquid formulations of indaziflam for crop safety. The data contained in this report was generated to register the use of indaziflam on and around environmental horticulture plants with over-the-top applications. The rates tested were 0.045, 0.089 and 0.178 pounds active ingredient per acre (lb ai per A) as the 1X, 2X and 4X rates. The indaziflam 0.03%G formulation was applied to 17 plant genera or species, the Marengo G formulation applied to 34 crops, and the Marengo 74SC liquid formulation applied to 26 genera or species. Of these crops, 9 exhibited no or minimal transient injury after application at all three rates including Aucuba japonica, Berberis sp., Liriope sp., Ophiopogon japonicus, Picea abies, Rhododendron sp., Rosa sp., Taxus media and certain Viburnum species. The remaining crops evaluated have only been screened in 1 or two trials or exhibited minimal to significant injury. Further testing is required on many species before a conclusion can be made confirming crop safety.