Indemnify (fluopyram) is a new fungicide being developed by Bayer for the control of nematodes; the current product is only registered for turf uses. The IR-4 Project has completed 37 crop safety trials on 18 environmental horticulture plant species or genera. Two crops (begonia, petunia) exhibited differential responses between foliar and drench applications with no to slight injury observed with foliar sprays, but moderate to severe injury with soil drenches. Four additional crops also did not exhibit injury after foliar or soil applications. Additional data are needed for 12 other crops (including foliar application on petunia) are needed for a definitive conclusion on crop safety.