Fluopyram (ESP 715, Indemnify) is a new fungicide being developed by Bayer for the control of nematodes, needle cast diseases powdery mildew, Fusarium, Botrytis, Sclerotinia, Corynespora, leaf spots and other foliar diseases. The IR-4 Project completed 14 crop safety trials on 7 ornamental horticulture plant species or genera in 2016. One genera (Begonia sp.) exhibited damage sufficient to recommend growers not utilize Fluopyram. Insufficient data were obtained for other species or genera for a definitive conclusion on crop safety.